溫度敏感Thermo-TRP通道結合人體生理指標在室內熱環境營造中的應用探索
Application exploration of thermal sensitive physiological indices and Thermo-TRP channels for building indoor comfortable and healthy environments
摘要：
營造舒適健康室內熱環境，提升建筑環境品質，滿足人們對美好生活的追求，同時盡可能實現建筑節能減碳，是建筑綠色低碳發展的必然要求。如何確定室內熱環境舒適區間，保障人員健康安全的室內熱環境如何設計，由于傳統熱環境設計和舒適評價主要依靠主觀問卷，缺少科學量化的回答，尤其是一直欠缺對人體熱舒適和人員熱健康的客觀度量。筆者及其課題組從建筑室內熱環境綠色營造的工程問題出發，通過選擇表征人體熱舒適敏感的生理指標，實現人體熱舒適從主觀評價到科學度量的根本轉變，解決了人體熱舒適客觀度量的科學問題；進而引入分子生物學研究手段和生化指標測量，探索了溫度敏感瞬時受體通道Thermo-TRP（thermal sensitive transient receptor potential）在不同溫度暴露下的激活和響應特性，確定了人體舒適溫度區間和健康安全閾值。人體生理熱調節是營造室內舒適健康熱環境的基礎，而分子生物學從微觀層面揭示機體調節機理，兩者的有機結合可以彌補建筑環境中對人體熱舒適機理認識不足和熱環境參數設計健康安全閾值不明確的不足，為建筑環境領域引入學科交叉研究方法、應用基礎科學成果解決實際工程問題提供新的研究思路和案例示范。
Abstract：
Improving the health and comfort of building environments and achieving energy efficiency and carbon emission reduction without compromising the quality of the living environments is an inevitable requirement for the development of energy efficient and intelligent buildings in the future. However, how to define a comfortable environment and how to design parameters to ensure the people health and safety in indoors, relying only on the traditional subjective thermal comfort evaluation in buildings is not sufficient. Starting from the engineering problems, the study provides a scientific method for quantifying human thermal comfort based on large sample measurements on human sensitive physiological indices. Through introducing the molecular biological research and exploring the thermal sensitive Thermo-TRP channels, the study answers the engineering questions of comfort zone and safety thresholds. Understanding the physiological and thermal regulation of human body is the basis for the creation of indoor thermal environments, while molecular biology provides the molecular mechanism of temperature sensation at the micro level. This work is of benefit to understanding mechanism and design parameter in engineering practice and application. It provides a new insight and better basis for introducing interdisciplinary research methods into the field of building environment and applying basic scientific achievements to solve practical engineering problems.
Keywords:HVACdesign;thermalsensitivetransientreceptorpotential(Thermo-TRP);humanphysiologicalresponse;indoorthermalenvironment;humanthermalcomfort;thermalhealth